How to reprogram human fibroblasts to neurons
نویسندگان
چکیده
منابع مشابه
CEND1 and NEUROGENIN2 Reprogram Mouse Astrocytes and Embryonic Fibroblasts to Induced Neural Precursors and Differentiated Neurons
Recent studies demonstrate that astroglia from non-neurogenic brain regions can be reprogrammed into functional neurons through forced expression of neurogenic factors. Here we explored the effect of CEND1 and NEUROG2 on reprogramming of mouse cortical astrocytes and embryonic fibroblasts. Forced expression of CEND1, NEUROG2, or both resulted in acquisition of induced neuronal cells expressing ...
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We have recently demonstrated that reactive glial cells can be directly reprogrammed into functional neurons by a single neural transcription factor, NeuroD1. Here we report that a combination of small molecules can also reprogram human astrocytes in culture into fully functional neurons. We demonstrate that sequential exposure of human astrocytes to a cocktail of nine small molecules that inhi...
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الهای متمادی است که سرویس های بهداشتی گلوتار آلدئید را بعنوان یک ماده استریل کننده برای وسایلی که نسبت به گرما حساس هستند مورد استفاده قرار می دهند. همزمان با افزایش تقاضا برای استفاده از اندوسکوپی، استفاده از گلوتار آلدئید و تماس با آن نیز افزایش یافته است. باید خاطر نشان ساخت گلوتار آلدئید می تواند سبب ایجاد حساسیت های پوستی، چشمی و تنفسی گردد که نهایتاً امکان دارد این حساسیت به آسم و رنیت آل...
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ژورنال
عنوان ژورنال: Cell & Bioscience
سال: 2020
ISSN: 2045-3701
DOI: 10.1186/s13578-020-00476-2